BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants
نویسندگان
چکیده
The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regarding BMP-functionalised coatings for orthopaedic implants.
منابع مشابه
Cell-mediated protein release from calcium-phosphate-coated titanium implants.
Implants used in dental and orthopaedic surgery should become osseointegrated into native bone. In an endeavour to potentiate bone formation, prostheses, coated with a coprecipitated layer of calcium phosphate and the osteogenic agent BMP-2, were implanted at an ectopic site in rats. Five weeks later, the implants were surrounded by a substantial mass of bone. Our findings indicate that the dru...
متن کاملBioactive Coatings for Orthopaedic Implants—Recent Trends in Development of Implant Coatings
Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic loosening and infection are the two most significant causes of prosthetic implant failure. The ideal implant should be able to promote osteointegration, deter bacterial adhesion and minimize prosthetic infection. Recent developments in material science and cell biology have seen the development of new...
متن کاملEnhanced osteointegration of orthopaedic implant gradient coating composed of bioactive glass and nanohydroxyapatite.
We conducted histologic and histomorphometric studies to evaluate the osteointegration of gradient coatings composed of bioactive glass and nanohydroxyapatite (BG-nHA) on titanium-alloy orthopaedic implants and surrounding bone tissue in vivo. Titanium-alloy implants with a gradient coating (gradient coating group), uncoated implants (uncoated group), and implants with a conventional hydroxyapa...
متن کاملEnhanced osteogenic activity and anti-inflammatory properties of Lenti-BMP-2-loaded TiO2 nanotube layers fabricated by lyophilization following trehalose addition
To enhance biocompatibility and osseointegration between titanium implants and surrounding bone tissue, numerous efforts have been made to modify the surface topography and composition of Ti implants. In this paper, Lenti-BMP-2-loaded TiO2 nanotube coatings were fabricated by lyophilization in the presence of trehalose to functionalize the surface. We characterized TiO2 nanotube layers in terms...
متن کاملMultifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants.
The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while i...
متن کامل